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File:Paracetamol metabolism.svg


English: Simplified schematic of the key pathways of paracetamol metabolism in the human body. The first step in conversion of paracetamol to NAPQI has been omitted for clarity.
Set in Myriad Pro.
   Pathways to non-toxic metabolites
   Pathway to toxic metabolites ( CYP-mediated)
   Detoxification pathway
GlcA, glucuronic acid; GSH, glutathione; NAPQI, N-acetyl-p-benzoquinone imine.
Português: Esquema simplificado das principais vias de biotransformação do paracetamol em humanos. Para maior clareza, omitiu-se a primeira etapa da conversão do paracetamol à N-acetil-benzoquinoneimina.
Diagrama composto em Myriad Pro.
   Vias de conversão a metabólitos atóxicos
   Via de conversão a metabólitos tóxicos (mediada pelo sistema P450)
   Via de detoxificação
GlcA, ácido glicurônico; GSH, glutationa; NAPQI, N-acetil-benzoquinoneimina.
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Date 18 January 2009
Source Own work, after Henry, John (1995). “ Poisoning”, in Marshall, William Leonard. Clinical biochemistry: metabolic and clinical aspects, p. 666, Edinburgh: Churchill Livingstone, ISBN 9780443043413; and Hendrickson, Robert G.; Kenneth E. Bizovi (2006). “ Acetaminophen”, in Nelson, Lewis H.; Flomenbaum, Neal; Goldfrank, Lewis R. et al. Goldfrank's toxicologic emergencies, p. 525, New York: McGraw-Hill, ISBN 9780071437639. Both retrieved on January 18, 2009 through Google Book Search.
Author Fvasconcellos ( talk · contribs)
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